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Studies on Fasting 2

International Journal of Ramadan Fasting Research 2:18, 1998
Abstracts of Selected Articles on Ramadan Fasting, 1997-98,
Compiled by M.Z.A. Nomani 1997:

Title: Fasting during Ramadan induces a marked increase in high-density lipoprotein cholesterol and decrease in low-density lipoprotein cholesterol.

Authors: Ahmed Adlouni1, Nosreddine Ghalim2, Abdellah Benslimane2, Jean Mechel Lecerf 3and Rachid Saile1

Institution: 
1  Laboratoire de recherches sur les lipoproteines, Department de Biologie, Faculte des Sciences Ben M'sik, and 
2  Laboratoire des Lipoproteines, Insitut Pasteur du Maroc, Casabalanca, Morocco; 
3  Service de Nutrition, Institut Pasteur de Lille, France

Source: Annals of Nutrition and Metabolism, 41: 242-249, 1997.

Abstract: 
The study was conducted on 32 healthy adult male volunteers. A significant decrease (7.9%, p<0.001) in serum total cholesterol and triglycerides (30%, p<0.001)concentration during Ramadan as compared with the pre-fasting period. By the end of Ramadan , serum HDL cholesterol had markedly increased (14.3%, p<0.001) and remained elevated one month after Ramadan, in contrast LDl cholesterol level showed a significant decrease (11.7%, p<0.001) and alos maintained one month after Ramadan. Mean body weight declined by 2.6% (p<0.1) on day 29 of Ramadan. Saturated fatty acid intake decreased during Ramadan. Under the prevailing conditions and feeding behavior of the subjects in the study, beneficial affects of Ramadan fasting on plasma lipids and lipoproteins were noted.

 

Title: Pharmacists, medicines and the fast of Ramadan

Authors: Mohamed Aslam and1 and John Wilson2

Institution: 
1   Senior Lecturer and Course Director in Clinical Pharmacy, Department of Pharmaceutical Sciences, University of Nottingham, 
2   Pharmaceutical Advisor to Nottingham Health Authority

Sources: Pharmaceutical Journal, 259:973-975, 1967

Abstract: 
A review article. The authors concluded that a failure to comply with prescribed dosage regimens during Ramadan can jeopardise the health of Moslems with certain medical conditions. Pharmacists need to be aware of the problems of their possible solutions.

 

Title: Effect pf Ramadan fasting on intragastric pH recorded during 24 hours in healthy subjects

Authors: L. Iraki, A. Abkari, T Vallot, N. Amrani, R.H. Khlifa, K. Jellouli and F. Hakkou

Institution: Fondation Hassan II pour la Recherche Scientifique et Medicale sur le Ramadan, Casablanca, Morocco

Source: Gastroenterol Clin Biol, 21(11): 813-819, 1967

Abstract: 
The aim of this study was to evaluate the influence of Ramadan on gastric acidity in healthy volunteers. Nine healthy volunteers had 24-hour measurement of the gastric pH. The diurnal variations of the pH profile were more significant; the median pH was 2.3 prior to Ramadan, 1 at day 10 and day 24, and 1.6 one month after Ramadan. The authors concluded that the conditions of feeding imposed by Ramadan are associated with an increase of the gastric acidity mainly in diurnal phase. The results do not explain the origin of the healthy volunteer digestive symptoms encountered during Ramadan.

 

Title: Ramadan diet restrictions modify the circadian time structure in humans. A study on plasma gastrin, insulin, glucose and calcium and on gastric pH.

Authors: L. Iraki1, A. Bodan2, F. Hakkou1, N. Amrani3, A. Abkari4 and Y. Touitou2

Institution: 
1   Hassan II Foundation for Scientific and Medical Research on Ramadan, Faculte de Medecine et de Pharmacie, Casablanca, Morocco; 
2    Faculte de Medecine Pittie-Salpetriere, 75013 Paris, France; 
3   Service d'Exploration Fonctionnelle Digestive, Hospital Ibn Sina, Souissi, Rabat, Morocco; 
4   Hospital Bnou Roch, Service de P3, Casablanca, Morocco.

Source: Journal of Clinical Endocrinology and Metabolism, 82(1): 1261-1273, 1997.

Abstract: 
A group of nine healthy male control subjects (mean age 25 and BW 73.3kg) and six HDU ( healed duodenal ulcer) patients (mean age 39 and BW 64), who were all healed from the ulcer for more than 3 months, were studied before (controls), during and after the month of Ramadan. The protocol wa approved by the Ethical Committee of the Faculte de Medecine and by the religious board of the Hassan II Foundation for Scientific and Medical Research on Ramadan. The time-restricted food and water intakes were associated with variations o gastric pH, plasma gastrin, insulin, glucose, and calcium documented on a cercadian basis. All of the studied biological variables, except insulin, underwent changes in their 24-h mean concentration (e.g. decrease in gastric pH, increase in plasma gastrin), some of which were still present one month after the end of Ramadan. The circadian patterns of all the studied variables were altered during the month of Ramadan. The authors concluded that some differences between the group of healthy control subjects and the HDUgroup may suggest a greater susceptibility of the latter to the modifications of feeding and sleeping schedule, which could possibly be a risk factor for the disease.

 

Title: Fasting and physiological parameters: Time for standardization of research methodology

Authors: Layla Mammo1 and Jalal Saour2

Institution: 
1   Depaartment of Biological and Medical Research and 
2   Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyad, Saudi Arabia

Source: Research Centre Bulletin, A Journal of Bilogical & Medical Research, 79(1&2):34-35, 1967.

Abstract: 
A review article. Ramadan fasting entails major changes in sleep pattern, physical activity and eating habits which may cause changes in metabolism both in health and disease. Because of non-standardization of research methodology, data available on Ramadan fasting is almost always conflicting. Variables that are often overlooked or not reported include the time of year and season when data were collected - in particular whether Ramadan fell during long hot summer days or short cold winter days. Further, the authors pointed that due to diverse social and economic differences to expect identical results is unrealistic. However, it is very clear that millions of healthy Moslems have fasted for many generations without obvious ill effects.

 

Title: Beneficial effect on serum apo AI, apo B and Lp AI levels of Ramadan fasting.

Authors: A. Adlouni, N. Ghalim, R. Saile, N. Hda and A. Benslimane

Institution: Department de Biologie, Faculte des Sciences Ben M'sik, Casablanca, Morocco

Source: Clin Chim Acta, 271(2):179-189, 1998

Abstract: 
In a group of 32 healthy, volunteer adult males the levels of serum apolipoproteins; apolipoprotein AI (Apo AI), apo B, apo AIV and those of lipoprotein particles; apo AI-containing lipoprotein particles (Lp AI) and also apo AII containing lipoprotein particles (Lp AI:AII), were determined on each week of the month of Ramadan. The results were compared with the pre-fasting and the post-fasting values. Ramadan fasting reduced significantly serum apo B (p<0.05), while serum apo AI was significantly increased (p<0.05) compared with the pre-fasting period. The increase of apo AI occurred on day 29 of Ramadan by 11.8%. Serum apo AIV was unchanged during the fasting period indicating that food intake during Ramadan is not based on lipid diet. The observed diet pattern during Ramadan showed an increase of total energy intake base on carbohydrates(+1.4% of the total energy), proteins (+0.4% of total energy) but not on fat (-0.7 of total energy), compared with a usual diet used in the rest of the year. The fat diet was high in monounsaturated (p<0.05) and polyunsaturated fatty acid in contrast to saturated fatty acid which decreased (p<0.01) during Ramadan. Analysis of serum Lp AI and Lp AI:AII showed that the levels of Lp AI:AII were unchanged but hose of Lp AI were significantly increased (p<0.01) at the end of Ramadan. These finding show that feeding behavior that occurs during Ramadan beneficially affects serum apolipoprotein metabolism and may contribute to prevention of cardiovascular diseases.

 

Title: Appetite changes under free-living conditions during Ramadan fasting

Authors: G.M. Finch, J.E.L. Day, Razak, D.A. Welch and P.J. Rogers

Institution: Department of Consumer Sciences, Institute of Food Research

Source: Appetite 31(2):159-170, 1998

Abstract: A group of healthy Muslims (15 men and 26 women) living in Reading, U.K. made hourly rating of their hunger, mood and thirst, and recorded their food and drink intake on specified days before, during and after Ramadan between January and March 1996. There were no significant changes in body weight over Ramadan. Rated hunger increased substantially during the daily fast, and hunger was higher for the women than the men during the earlier days of Ramadan, whereas later, on average, fasting levels of hunger were very similar for both sexes (significant gender x day interaction, p<0.01). During Ramadan, the men tended to spend much of their time away from home, and may therefore have largely avoided eating-related cues during the daily fast. The women, however, were frequently involved in preparing food to be eaten later after sunset, which suggests an explanation for the results based on the external cue control of hunger. That is, unreinforced exposure to food cues in this context may have led to a decrease in the capacity of these cues to stimulate hunger.

 

Title: Variations of blood pressure during the month of Ramadan

Authors: R. Habbal, L. Azzouzi, K. Adnan, A. Tahiri, N. Chraibi

Institution: Centre de cardiologie, Centre hospitalier universitaire Ibn Roch, Casablanca, Morocco

Source: Arch Mal Coeur Vaiss, 91(8): 995-998, 1998.

Abstract: 
The study included 72 women and 27 men. From 1994 to 1997 the selected hypertensive patients and their BP profile was studied. Their age varied from 22 to 72 years (average 56.7±9). All these patients had an ambulatory blood pressure measurement (ABPM) before the fast and during Ramadan. Before Ramadan the period of the sleep was from 10 pm ±1 h to 8 am ± 1 h. During the month of Ramadan, the sleep lasts from 0 h±1 to 9 am ±1 h. No statistically significant difference was noted between these two periods. The average hourly observations on 24 hours of the 99 patients was estimated. The authors observed that during the month of Ramadan the peak of the awakening was delayed by two hours and the nocturnal delayed by one hour. It was concluded that in patients with essential hypertension without complications, the Ramadan fast is well supported. The variations of BP are minimal and are related to the variations of the sleep, activity and eating pattern.

 

Title: Gorging and plasma HDL-cholesterol--the Ramdan Model.

Authors: M. Maislos, Y. Abou-Rabiah, I Zuili, S. Iordash and S. Shany

Institution: Department of Medicine, Toor Institute, Israel

Source: European Journal of Clinical Nutrition. 52(2): 127-130, 1998

Abstract: 
The objective of the study was to evaluate the effect of a single evening meal (gorging) on plasma lipids and lipoprotiens in normal inidividuals observing Ramadan fast. The study was conducted in the Bedouin town of Rahat, in the northern Negevvarea of Israel. Twenty-two healthy subjects who fasted during Ramadam and 16 non-fasting laboratory workers, were studied before Ramadan, at week 1, 2 and 4 of the Ramadan month, an again four weeks after the end of Ramadan.

   

Source: 
International Journal of Ramadan Fasting Research
     http://www.labs.net/ains/ramadan.htm

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